TWO SITES PHOSPHONYLATION OF SALICIN WITH DISODIUM DIPHOSPHONATE IN AQUEOUS SOLUTION

Abstract

Phosphonylation of salicin has been achieved using inorganic disodium diphosphonate (DP) in aqueous solution. The optimum condition for the phosphonylation of salicin with DP is salicin : DP = 0.1 mol/L : 1.0 mol/L, pH 12 and 25°C. 2’, 4’-Diphosphonylsalicin was synthesized with the yield of 50%. We have successfully introduced the two phosphonate groups in one molecule. The reaction mechanism of salicin with DP was discussed.