Fabrication of Dissolvable Coated Thin-film Mask with Biodegradable Microneedles by Drawing Lithography for Efficient Transdermal Drug Delivery

抄録

Conventional transdermal patch has been widely utilized to deliver specific medication through the skin. In recent decades, microneedles have been intensively researched and developed as a novel technique for transdermal drug delivery to achieve advantages such as minimally invasive and efficient drug delivery. Especially, dissolvable microneedles made of biodegradable materials loaded with specific drug that is released into skin after insertion are more focused. In this research, dissolvable coated thin-film mask with biodegradable microneedles on it was fabricated to achieve drug delivery enhancement. 10 % (w/w) Hyaluronic acid (HA) solution, as a biodegradable and biocompatible material, was evenly coated on water-soluble Poly(vinyl alcohol) (PVA) substrate. After drying, the thickness of solidified coated film was around 10 μm. For microneedles fabrication, drawing lithography method was utilized. Poly(methyl methacrylate) (PMMA) stamps fabricated by 3D printing technology with pillar arrays for stamping were designed with 1.5 mm diameter and 2mm spacing to adhere the 20% (w/w) HA solution for drawing at the room temperature. In a result, microneedles arrays were fabricated on the dissolvable HA and PVA substrate with the height of 400 μm〜800 μm. Large-sized dissolvable transdermal patch with biodegradable microneedles could be fabricated in this approach. The red Rhodamine B was used as model drug in the research.