Effect of centrifuge-induced artificial gravity and ergometric exercise on cardiovascular deconditioning, myatrophy, and bone metabolism by simulated microgravity

Satoshi Iwase; Junichi Sugenoya; Maki Sato; Yuuki Shimizu; Hiroki Takada; Tadaaki Mano; Koji Ishida; HIroshi Akima; Keisho Katayama; Kaname Hirayanagi; Ken-ichi Iwasaki; Tomoki Shiozawa; Kazuyoshi Yajima; Mitsunori Iwase; Yoriko Watanabe; Satomi Suzuki; Tetsuo Fukunaga; Yoshihisa Masuo

doi:10.14849/psjproc.2007.0_189_2

Proceedings of Annual Meeting of the Physiological Society of Japan

Session ID : 2PIP-025

DOI https://doi.org/10.14849/psjproc.2007.0_189_2

Conference information

Effect of centrifuge-induced artificial gravity and ergometric exercise on cardiovascular deconditioning, myatrophy, and bone metabolism by simulated microgravity

*Satoshi Iwase, Junichi Sugenoya, Maki Sato, Yuuki Shimizu, Hiroki Takada, Tadaaki Mano, Koji Ishida, HIroshi Akima, Keisho Katayama, Kaname Hirayanagi, Ken-ichi Iwasaki, Tomoki Shiozawa, Kazuyoshi Yajima, Mitsunori Iwase, Yoriko Watanabe, Satomi Suzuki, Tetsuo Fukunaga, Yoshihisa Masuo

Author information

*Satoshi Iwase
Dept. Physiol. Aichi Med. Univ., Nagakute, Aichi, Japan
Junichi Sugenoya
Dept. Physiol. Aichi Med. Univ., Nagakute, Aichi, Japan
Maki Sato
Dept. Physiol. Aichi Med. Univ., Nagakute, Aichi, Japan
Yuuki Shimizu
Dept. Physiol. Aichi Med. Univ., Nagakute, Aichi, Japan
Hiroki Takada
Dept. Physiol. Aichi Med. Univ., Nagakute, Aichi, Japan
Tadaaki Mano
Gifu University of Medical Science, Seki, Japan
Koji Ishida
Institute of Physical Fitness and Sports, Nagoya University, Nagoya Japan
HIroshi Akima
Institute of Physical Fitness and Sports, Nagoya University, Nagoya Japan
Keisho Katayama
Institute of Physical Fitness and Sports, Nagoya University, Nagoya Japan
Kaname Hirayanagi
Dept Hygiene, Nihon University School of Medicine, Tokyo, Japan
Ken-ichi Iwasaki
Dept Hygiene, Nihon University School of Medicine, Tokyo, Japan
Tomoki Shiozawa
Dept Hygiene, Nihon University School of Medicine, Tokyo, Japan
Kazuyoshi Yajima
Sano Junior College, Sano, Japan
Mitsunori Iwase
Toyota Memorial Hospital, Toyota, Japan
Yoriko Watanabe
School of Nursing, Seirei Christopher University, Hamamatsu, Japan
Satomi Suzuki
School of Nursing, Aichi Medical University, Nagakute, Japan
Tetsuo Fukunaga
School of Human Science, Waseda University, Tokorozawa, Japan
Yoshihisa Masuo
School of Human Science, Waseda University, Tokorozawa, Japan

Keywords: microgravity, artificial gravity, sympathetic nervous system, deconditioning, spaceflight

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Abstract

To test the effectiveness of centrifuge-induced artificial gravity with ergometric exercise, 12 healthy young men were exposed to simulated microgravity for 20 days of head-down bedrest. Half the subjects were randomly selected and loaded 1.2 G artificial gravity with 60 W of ergometric workload everyday(CM group). The rest of the subjects served as the control. Anti-G score, defined as the G-load; running time to the endpoint, was significantly elongated by the load of the centrifuge-ergometer. Centrifuge-induced artificial gravity with exercise is effective in preventing cardiovascular deconditioning due to microgravity exposure, however, an effective and appropriate regimen (magnitude of G-load and exercise workload) should be determined in future studies. [J Physiol Sci. 2007;57 Suppl:S189]

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