FEEDING RESPONSES ELICITED BY THE ELECTRICAL STIMULATION OF LATERAL HYPOTHALAMUS IN THE CAT

MAMORU UMEMOTO; RYONOSUKE KIDO

doi:10.4992/psycholres1954.9.14

THE EFFECTS OF METHAMPHETAMINE

MAMORU UMEMOTO, RYONOSUKE KIDO

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JOURNALS FREE ACCESS

Volume 9 (1967) Issue 1 Pages 14-19

DOI https://doi.org/10.4992/psycholres1954.9.14

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Released: February 24, 2009 [Advance Publication] Released: - received: November 05, 1966 corrected: - accepted: -
Correction information
Date of correction: February 24, 2009 Reason for correction: - Correction: ABSTRACT Details: Wrong : In stimulating to the lateral hypothalamic area (HL) electrically, eating responses which bound to stimulation directly were obtained in 15 out of 98 cats. These animals discriminated between edible and inedible objects. Successive behavioral changes were observed in varing the parameters (voltage or frequency) of stimulation. The loci eliciting the above responses lay in the external part of HL at the level of the ventromedial hypothalamus (Hvm). Diffuse area in HL commonly produced sniffing responses. Low-voltage fast activity appeared in Hvm lead selectively when the cat was eager to get food after 24 hr starvation. Methamphetamine (2.0mg/kg i.v.) elevated the threshold of stimulus intensity during 15-30 min after injection.
Right : In stimulating to the lateral hypothalamic area (HL) electrically, eating responses which bound to stimulation directly were obtained in 15 out of 98 cats. These animals discriminated between edible and inedible objects. Successive behavioral changes were observed in varing the parameters (voltage or frequency) of stimulation. The loci eliciting the above responses lay in the external part of HL at the level of the ventromedial hypothalamus (Hvm). Diffuse area in HL commonly produced sniffing responses.
Low-voltage fast activity appeared in Hvm lead selectively when the cat was eager to get food after 24hr starvation.
Methamphetamine (2.0mg/kg i. v.) elevated the threshold of stimulus intensity during 15-30 min after injection.

Date of correction: February 24, 2009 Reason for correction: - Correction: AUTHOR Details: Wrong : MAMORU UMEMOTO¹⁾, RYONOSUKE KIDO²⁾
Right : MAMORU UMEMOTO¹⁾, RYONOSUKE KIDO¹⁾

Date of correction: February 24, 2009 Reason for correction: - Correction: AFFILIATION Details: Wrong :
1) Division of Neurobharmtacology, Shionogi Research Laboratory
2) Shionogi and Co., Ltd.

Right :
1) Division of Neuropharntacology, Shionogi Research Laboratory, Shionogi and Co., Ltd.

Date of correction: February 24, 2009 Reason for correction: - Correction: CITATION Details: Wrong : ANAND, B. K., & BROBECK, J. R. 1951 Hypothalamic control of food intake in rats and cats. Yale J. Biol. Nled., 24, 123-140.
ANAND, B. K., DUA, S., & SHOENBERG, K. 1955 Hypothalamic control of food intake in the cat and monkey. J. Physiol., 127, 143-152.
BROBECK, J. R., LARSSON, S., & REYES, E. 1956 A study of the electrical activity of the hypothalamic feeding mechanism. J. Physiol., 132, 358-364.
BRUGGER, M. 1943 Fresstrieb als hypothalami sches symptom. Helr. Physiol. Acta., 1, 183-198.
DELGADO, J. M. R., & ANAND, B. K. 1953 Increase of food intake induced by electrical stimulation of the lateral hypothalamus. Amer. J. Physiol. 172, 162-168.
HAMILTON, C. L., & BROBECK, J. R. 1964 Hypothalamic hyperphagia in the monkey. J. Comp. Physiol. Psychol. 57, 271-278.
HESS, W. R. 1956 Hypothalamus and thalamus. Documentary pictures. Stuttgard: Thieme.
HETHERINGTON, A. W., & RANSON, S. W. 1942 The spontaneous activity and food intake of rat with hypothalamic lesions. Amer. J. Physiol. 136, 609-617.
HOCKMAN, C. H. 1964 EEG and behavioral effects of food deprivation in the albino rat. EEG clin. Neurophysiol. 17, 420-427.
HUNTER, J., & JASPER, H. H. 1949 Effects of thalamic stimulation in anesthetized animals; arrest reaction and petitemal-like seizures activation patterns and generalizes convulsions. EEG clin. . Neurophysiol. 1, 305-324.
MILLER, N. E. 1960 Motivational effects of brain stimulation and drugs. Fed. Proc. 19, 846-854.
MORGANE, P. J. 1961 Electrophysiological studies of feeding and satiety centers in the rat. Amer. J. Physiol. 201, 838-844.
NAKAJIMA, J. L., GRANDJEAN, J. L., & THUILLIER, J. 1964 Neuro-stimulants hallucinogenes et non hullucinogenes: Confrontation experimentale de leurs effects sur les temperatures centrale et peripherique. Biochemical and neurophysiological correlation of centrally acting drugs. Trabucchi, E. (ed.), Pergamon Press Ltd. Oxford.
OOMURA, Y., KIMURA, K., OOYAMA, H., MAENO, T., IKI, M., & KUNIHOSHI, M. 1964 Reciprocal activities of the ventromedial and lateral hypothalamic area of cats. Science, 143, 484-485.
SHARMA, K. N., ANAND, B. K., DUA, S., & SINGH, B. 1961 Role of stomach in reguration of activities of hypothalamic feeding centers. Amer. J. Physiol. 201, 593-598.
STEVENSON, J., & MONTEMMRRO, D. 1963 Loss of weight and metabolic rate of lesions in the medial and lateral hypothalamus. Nature. 198, 92.

Right : ANAND, B. K., & BROBECK, J. R. 1951 Hypothalamic control of food intake in rats and cats. Yale J. Biol. Med., 24, 123-140.
ANAND, B. K., DUA, S., & SHOENBERG, K. 1955 Hypothalamic control of food intake in the cat and monkey. J. Physiol., 127, 143-152.
BROBECK, J. R., LARSSON, S., & REYES, E. 1956 A study of the electrical activity of the hypothalamic feeding mechanism. J. Physiol., 132, 358-364.
BRUGGER, M. 1943 Fresstrieb als hypothalamisches symptom. Helv. Physiol. Acta., 1, 183-198.
DELGADO, J. M. R., & ANAND, B. K. 1953 Increase of food intake induced by electrical stimulation of the lateral hypothalamus. Amer. J. Physiol. 172, 162-168.
HAMILTON, C. L., & BROBECK, J. R. 1964 Hypothalamic hyperphagia in the monkey. J. Comp. Physiol. Psychol. 57, 271-278.
HESS, W. R. 1956 Hypothalamus and thalamus. Documentary pictures. Stuttgard: Thieme.
HETHERINGTON, A. W., & RANSON, S. W. 1942 The spontaneous activity and food intake of rat with hypothalamic lesions. Amer. J. Physiol. 136, 609-617.
HOCKMAN, C. H. 1964 EEG and behavioral effects of food deprivation in the albino rat. EEG clin. Neurophysiol. 17, 420-427.
HUNTER, J., & JASPER, H. H. 1949 Effects of thalamic stimulation in anesthetized animals; arrest reaction and petitemal-like seizures activation patterns and generalizes convulsions. EEG clin. Neurophysiol. 1, 305-324.
MILLER, N. E. 1960 Motivational effects of brain stimulation and drugs. Fed. Proc. 19, 846-854.
MORGANE, P. J. 1961 Electrophysiological studies of feeding and satiety centers in the rat. Amer. J. Physiol. 201, 838-844.
NAKAJIMA, J. L., GRANDJEAN, J. L., & THUILLIER, J. 1964 Neuro-stimulants hallucinogenes et non hullucinogenes: Confrontation experimentale de leurs effects sur les temperatures centrale et peripherique. Biochemical and neurophysiological correlation of centrally acting drugs. Trabucchi, E.(ed.), Pergamon Press Ltd. Oxford.
OOMURA, Y., KIMURA, K., OOYAMA, H., MAENO, T., IKI, M., & KUNIHOSHI, M. 1964 Reciprocal activities of the ventromedial and lateral hypothalamic area of cats. Science, 143, 484-485.
SHARMA, K. N., ANAND, B. K., DUA, S., & SINGH, B. 1961 Role of stomach in reguration of activities of hypothalamic feeding centers. Amer. J. Physiol. 201, 593-598.
STEVENSON, J., & MONTEMMRRO, D. 1963 Loss of weight and metabolic rate of lesions in the medial and lateral hypothalamus. Nature. 198, 92.

Date of correction: February 24, 2009 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: February 24, 2009 Reason for correction: - Correction: ABSTRACT Details: Wrong : In stimulating to the lateral hypothalamic area (HL) electrically, eating responses which bound to stimulation directly were obtained in 15 out of 98 cats. These animals discriminated between edible and inedible objects. Successive behavioral changes were observed in varing the parameters (voltage or frequency) of stimulation. The loci eliciting the above responses lay in the external part of HL at the level of the ventromedial hypothalamus (Hvm). Diffuse area in HL commonly produced sniffing responses.
Low-voltage fast activity appeared in Hvm lead selectively when the cat was eager to get food after 24hr starvation.
Methamphetamine (2.0mg/kg i. v.) elevated the threshold of stimulus intensity during 15-30 min after injection.
Right : In stimulating to the lateral hypothalamic area (HL) electrically, eating responses which bound to stimulation directly were obtained in 15 out of 98 cats. These animals discriminated between edible and inedible objects. Successive behavioral changes were observed in varing the parameters (voltage or frequency) of stimulation. The loci eliciting the above responses lay in the external part of HL at the level of the ventromedial hypothalamus (Hvm). Diffuse area in HL commonly produced sniffing responses.
Low-voltage fast activity appeared in Hvm lead selectively when the cat was eager to get food after 24 hr starvation.
Methamphetamine (2.0 mg/kg i. v.) elevated the threshold of stimulus intensity during 15-30 min after injection.

Date of correction: February 24, 2009 Reason for correction: - Correction: AFFILIATION Details: Wrong :
1) Division of Neuropharntacology, Shionogi Research Laboratory, Shionogi and Co., Ltd.

Right :
1) Division of Neuropharmacology, Shionogi Research Laboratory, Shionogi and Co., Ltd.

Date of correction: February 24, 2009 Reason for correction: - Correction: CITATION Details: Wrong : ANAND, B. K., & BROBECK, J. R. 1951 Hypothalamic control of food intake in rats and cats. Yale J. Biol. Med., 24, 123-140.
ANAND, B. K., DUA, S., & SHOENBERG, K. 1955 Hypothalamic control of food intake in the cat and monkey. J. Physiol., 127, 143-152.
BROBECK, J. R., LARSSON, S., & REYES, E. 1956 A study of the electrical activity of the hypothalamic feeding mechanism. J. Physiol., 132, 358-364.
BRUGGER, M. 1943 Fresstrieb als hypothalamisches symptom. Helv. Physiol. Acta., 1, 183-198.
DELGADO, J. M. R., & ANAND, B. K. 1953 Increase of food intake induced by electrical stimulation of the lateral hypothalamus. Amer. J. Physiol. 172, 162-168.
HAMILTON, C. L., & BROBECK, J. R. 1964 Hypothalamic hyperphagia in the monkey. J. Comp. Physiol. Psychol. 57, 271-278.
HESS, W. R. 1956 Hypothalamus and thalamus. Documentary pictures. Stuttgard: Thieme.
HETHERINGTON, A. W., & RANSON, S. W. 1942 The spontaneous activity and food intake of rat with hypothalamic lesions. Amer. J. Physiol. 136, 609-617.
HOCKMAN, C. H. 1964 EEG and behavioral effects of food deprivation in the albino rat. EEG clin. Neurophysiol. 17, 420-427.
HUNTER, J., & JASPER, H. H. 1949 Effects of thalamic stimulation in anesthetized animals; arrest reaction and petitemal-like seizures activation patterns and generalizes convulsions. EEG clin. Neurophysiol. 1, 305-324.
MILLER, N. E. 1960 Motivational effects of brain stimulation and drugs. Fed. Proc. 19, 846-854.
MORGANE, P. J. 1961 Electrophysiological studies of feeding and satiety centers in the rat. Amer. J. Physiol. 201, 838-844.
NAKAJIMA, J. L., GRANDJEAN, J. L., & THUILLIER, J. 1964 Neuro-stimulants hallucinogenes et non hullucinogenes: Confrontation experimentale de leurs effects sur les temperatures centrale et peripherique. Biochemical and neurophysiological correlation of centrally acting drugs. Trabucchi, E.(ed.), Pergamon Press Ltd. Oxford.
OOMURA, Y., KIMURA, K., OOYAMA, H., MAENO, T., IKI, M., & KUNIHOSHI, M. 1964 Reciprocal activities of the ventromedial and lateral hypothalamic area of cats. Science, 143, 484-485.
SHARMA, K. N., ANAND, B. K., DUA, S., & SINGH, B. 1961 Role of stomach in reguration of activities of hypothalamic feeding centers. Amer. J. Physiol. 201, 593-598.
STEVENSON, J., & MONTEMMRRO, D. 1963 Loss of weight and metabolic rate of lesions in the medial and lateral hypothalamus. Nature. 198, 92.

Right : ANAND, B. K., & BROBECK, J. R. 1951 Hypothalamic control of food intake in rats and cats. Yale J. Biol. Med., 24, 123-140.
ANAND, B. K., DUA, S., & SHOENBERG, K. 1955 Hypothalamic control of food intake in the cat and monkey. J. Physiol., 127, 143-152.
BROBECK, J. R., LARSSON, S., & REYES, E. 1956 A study of the electrical activity of the hypothalamic feeding mechanism. J. Physiol., 132, 358-364.
BRÜGGER, M. 1943 Fresstrieb als hypothalamisches symptom.Helv. Physiol. Acta., 1, 183-198.
DELGADO, J. M. R., & ANAND, B. K. 1953 Increase of food intake induced by electrical stimulation of the lateral hypothalamus. Amer. J. Physiol. 172, 162-168.
HAMILTON, C. L., & BROBECK, J. R. 1964 Hypothalamic hyperphagia in the monkey. J. Comp. Physiol. Psychol. 57, 271-278.
HESS, W. R.1956 Hypothalamus und thalamus. Documentary pictures. Stuttgard: Thieme.
HETHERINGTON, A. W., & RANSON, S. W. 1942 The spontaneous activity and food intake of rat with hypothalamic lesions. Amer. J. Physiol. 136, 609-617.
HOCKMAN, C. H. 1964 EEG and behavioral effects of food deprivation in the albino rat. EEG clin. Neurophysiol. 17, 420-427.
HUNTER, J., & JASPER, H. H. 1949 Effects of thalamic stimulation in anesthetized animals; arrest reaction and petitemal-like seizures activation patterns and generalizes convulsions. EEG clin.Neurophysiol. 1, 305-324.
MILLER, N. E.1960 Motivational effects of brain stimulation and drugs. Fed. Proc. 19, 846-854.
MORGANE, P. J. 1961 Electrophysiological studies of feeding and satiety centers in the rat. Amer. J. Physiol. 201, 838-844.
NAKAJIMA, J. L., GRANDJEAN, J. L., & THUILLIER, J. 1964 Neuro-stimulants hallucinogenes et non hullucinogenes: Confrontation experimentale de leurs effects sur les temperatures centrale et peripherique. Biochemical and neurophysiological correlation of centrally acting drugs. Trabucchi, E.(ed.), Pergamon Press Ltd. Oxford.
OOMURA, Y., KIMURA, K., OOYAMA, H., MAENO, T., IKI, M., & KUNIHOSHI, M. 1964 Reciprocal activities of the ventromedial and lateral hypothalamic area of cats. Science, 143, 484-485.
SHARMA, K. N., ANAND, B. K., DUA, S., & SINGH, B. 1961 Role of stomach in reguration of activities of hypothalamic feeding centers. Amer. J. Physiol. 201, 593-598.
STEVENSON, J., & MONTEMMRRO, D. 1963 Loss of weight and metabolic rate of lesions in the medial and lateral hypothalamus. Nature. 198, 92.

Abstract

In stimulating to the lateral hypothalamic area (HL) electrically, eating responses which bound to stimulation directly were obtained in 15 out of 98 cats. These animals discriminated between edible and inedible objects. Successive behavioral changes were observed in varing the parameters (voltage or frequency) of stimulation. The loci eliciting the above responses lay in the external part of HL at the level of the ventromedial hypothalamus (Hvm). Diffuse area in HL commonly produced sniffing responses.
Low-voltage fast activity appeared in Hvm lead selectively when the cat was eager to get food after 24 hr starvation.
Methamphetamine (2.0 mg/kg i. v.) elevated the threshold of stimulus intensity during 15-30 min after injection.

Released dates

Correction information

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