Semantic dementia (SD) is a neurodegenerative disorder featured selective loss of semantic memory associated with a focal atrophy of the anterior temporal lobes. The aim of this study was to describe the clinical features of SD and to propose a coping method as a care for the patients with SD. Difficulties in naming and recognition of words with surface dyslexia on kanji-word reading [gogi-aphasia] are the most prominent symptoms in the patient with the left-dominant temporal lobe atrophy, while misidentification of familiar persons [prosopagnosia] and/or misunderstanding of visual objects [associative agnosia] is the characteristic of the patient with the right-dominant temporal lobe atrophy. Either symptom, however, rather appeared common in almost every SD patient from longitudinal perspectives of progressive amodal semantic impairment. Then the persistent stereotypies at an early stage of the disease turned into prominent and huge destructive behavior and psychological symptoms of dementia (BPSD). Quality associated way of care for patients with SD, early exposure to daily cognitive skill training utilizing preserved abilities and stepwise application to the care-services is essential.