RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Serial Review on Clinical PET Tracers
Positron Emission Tomography with [11C]2-β-carbomethoxy-3β-(4-fluorophenyl)tropane for Dopamine Transporter
Yasuomi OUCHI
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JOURNALS OPEN ACCESS

2009 Volume 58 Issue 11 Pages 781-788

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Abstract

11C-CFT is a new radiotracer with a cocaine-structure and binds specifically to dopamine transporter located on the presynaptic dopaminergic terminal, which gives us in vivo information on dopamine transporter binding. The selectivity of 11C-CFT to the target region and the specificity of 11C-CFT is considerably high. The synthesis of the tracer is fairly stable. With these qualities, the tracer enables to illustrate the pathophysiology of Parkinson's disease(PD)or differentiate PD from brain disorders with parkinsonism. Moreover, it has been now in extensive use for other neurological and psychiatric diseases with dopaminergic abnormality. The clinical usefulness of 11C-CFT is described here.

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© 2009 by Japan Radioisotope Association
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