The Studies of in Vivo Distributions of Radioiodinated Cobalt-bleomycin in Tumor-bearing Animals by the Whole Body Autoradiography

Abstract

High tumor uptake of cobalt-bleomycin suggested that it would be a suitable starting material for chemical modification study. We already described the synthesis of 3-¹²⁵I-iodobenzyl cobalt-bleomycin and its in vivo distributions in tumor-bearing animals. In the present study, it was shown by the whole body autoradiogram that 3-¹²⁵I-iodobenzyl cobalt-bleomycin accumulated in tumor (dorsum, thigh, neck), the kidney, the liver and feces. Tumor affinity of this compound was proved by the results of the whole body autoradiogram.