RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
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The Studies of in Vivo Distributions of Radioiodinated Cobalt-bleomycin in Tumor-bearing Animals by the Whole Body Autoradiography
Atsushi AndoItsuko AndoHirohumi SudaKazuyuki NishimotoShintaro KameiJun KosakaYoshihiro NishiyamaYuka YamamotoMasahiro KurodaSusumu Kanazawa
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JOURNALS OPEN ACCESS

2017 Volume 66 Issue 8 Pages 307-310

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Abstract

High tumor uptake of cobalt-bleomycin suggested that it would be a suitable starting material for chemical modification study. We already described the synthesis of 3-125I-iodobenzyl cobalt-bleomycin and its in vivo distributions in tumor-bearing animals. In the present study, it was shown by the whole body autoradiogram that 3-125I-iodobenzyl cobalt-bleomycin accumulated in tumor (dorsum, thigh, neck), the kidney, the liver and feces. Tumor affinity of this compound was proved by the results of the whole body autoradiogram.

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© 2017 Japan Radioisotope Association
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