Measurement of Iodine-Derived Contamination in L-[11C]Methionine Injection

Yukiko Komatsu; Ken-ichi Nishijima; Shigeo Oomagari; Yasukazu Kanai; Sadahiro Naka; Kei Higashikawa; Yoko Ebita; Tohru Shiga; Jun Hatazawa; Nagara Tamaki; Yuji Kuge

doi:10.3769/radioisotopes.67.75

Articles

Measurement of Iodine-Derived Contamination in L-[¹¹C]Methionine Injection

Yukiko Komatsu, Ken-ichi Nishijima, Shigeo Oomagari, Yasukazu Kanai, Sadahiro Naka, Kei Higashikawa, Yoko Ebita, Tohru Shiga, Jun Hatazawa, Nagara Tamaki, Yuji Kuge

Author information

Yukiko Komatsu
Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University
Ken-ichi Nishijima
Central Institute of Isotope Science, Hokkaido University
Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University
Shigeo Oomagari
SHI Accelerator Service Co., Ltd.
Yasukazu Kanai
Department of Molecular Imaging in Medicine, Graduate School of Medicine, Osaka University
Sadahiro Naka
Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University
Kei Higashikawa
Central Institute of Isotope Science, Hokkaido University
Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University
Yoko Ebita
Central Institute of Isotope Science, Hokkaido University
Tohru Shiga
Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University
Jun Hatazawa
Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University
Nagara Tamaki
Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University
Yuji Kuge Corresponding author
Central Institute of Isotope Science, Hokkaido University
Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University

Keywords: L-[¹¹C]methionine, on-column synthesis, gas phase iodination, iodine-derived contamination

JOURNAL OPEN ACCESS

2018 Volume 67 Issue 3 Pages 75-83

DOI https://doi.org/10.3769/radioisotopes.67.75

Details

Abstract

Measurement methods for iodine-derived contamination in L-[¹¹C]methionine injection were evaluated. L-[¹¹C]Methionine injection and samples from the mock synthesis routes where iodine vapor was introduced with or without passing precolumns of sodium hydroxide-coated silica (Ascarite columns) were used. The contents of total iodine, iodide ion, and I₂ were determined by ICP-MS, HPLC-UV detection, and N,N-diethyl-1,4 phenylenediamine method, respectively. Total iodine contents measured by ICP-MS indicated the potentials of Ascarite columns for removing I₂ . The iodine-derived contamination existed as iodide ion in the L-[¹¹C]methionine injections. Accordingly, measurement of iodide ion by HPLC offers a rapid and useful means of controlling the manufacturing processes of L-[¹¹C]methionine injection.

Corresponding author

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