2019 Volume 68 Issue 10 Pages 693-700
In this review, recent findings are introduced in terms of particle irradiation-induced DNA damage and repair, particularly DNA double-strand break repair, by HIMAC. Based on the studies using HIMAC, the structure of complex DNA lesion as well as clustered DNA double-strand breaks after high LET particle irradiation hav been identified. In addition, the molecular mechanisms underlying DNA repair pathway choice after particle ion irradiation has been uncovered. The comprehensive understanding of molecular mechanism regarding DNA damage and its repair proposes potential novel approaches to augment the efficacy of particle radiotherapy. In this review, recent significant findings obtained by using HIMAC are introduced by focusing on DNA damage and repair.