RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Section 8 [Radiation Biology] Contribution of HIMAC for Radiation Biology
8.2.2 DNA Damage and Repair by Particle Beam
Atsushi Shibata
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JOURNALS OPEN ACCESS

2019 Volume 68 Issue 10 Pages 693-700

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Abstract

In this review, recent findings are introduced in terms of particle irradiation-induced DNA damage and repair, particularly DNA double-strand break repair, by HIMAC. Based on the studies using HIMAC, the structure of complex DNA lesion as well as clustered DNA double-strand breaks after high LET particle irradiation hav been identified. In addition, the molecular mechanisms underlying DNA repair pathway choice after particle ion irradiation has been uncovered. The comprehensive understanding of molecular mechanism regarding DNA damage and its repair proposes potential novel approaches to augment the efficacy of particle radiotherapy. In this review, recent significant findings obtained by using HIMAC are introduced by focusing on DNA damage and repair.

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© 2019 Japan Radioisotope Association
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