RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Effect of γ-oryzanol on Hepatic Cholesterol Biosynthesis and Fecal Excretion of Cholesterol Metablites
Haruo NAKAMURA
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1966 Volume 15 Issue 6 Pages 371-374

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Abstract

Administration of γ-oryzanol to mice at a dose of 1 mg/kg/day for 30 days resulted in a decreased incorporation of both acetate-1-14C and mevalonic acid-2-14C into hepatic cholesterol.
When γ-oryzanol was injected to mice at a dose of 1 mg/kg for 14 days, the drug caused an increas of the fecal excretion of total-14C, total sterol-14C, total bile acid-14C and nonsaponifiable material-14C derived from cholesterol-14C injection.
The supplementation of 0.01% of γ-oryzanol into antibiotic diet inhibited an increase of hepatic cholesterol level and a decrease of the incorporation of acetate-1-14C into hepatic cholesterol induced by feeding an antibiotic diet contained 2% of sulfathiazole and 0.4% of oxytetracycline to mice for 12 days.

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© Japan Radioisotope Association
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