The Whole Body Autoradiographic Studies on the Distribution of Radioisotopes (XIV)

Distribution of a Non-narcotic Central Antitussive Agent, 3- (1-methyl) -1-piperididene-di- (2'-thienyl) -methane (AV) in Mice

Abstract

The distribution of ³H or ¹⁴C-labelled AV was studied by whole body autoradiography in mice. The labelled AV was administered to mice by intraperitoneal, intravenous, subcutaneous and oral route and each distribution pattern was discussed. In any administration route, AV and/or its metabolites were highly accumulated in such tissues as the liver, kidney, lung, brown fat, salivary gland, harderian gland, gall bladder, gastrointestinal tracts and urinary bladder. This compound also revealed to be accumulated in brain at the first after intravenous injection and to be easily absorbed from the digestive tracts. Almost of AV and/or its metabolites were excreted in urine and feces within 24 hours after administration and retention of radioactivity was not observed in any tissue. The radioactive substances passed the placental barrier but radioactivity in fetuses was lower than that in maternal tissues.