A Tumor-specific Localizing Agent for Radioisotope Image (II)

—The Synthesis of 6-Iodopurine-¹³¹I and Its Distribution in Tumor Bearing Mice—

Abstract

6-Iodopurine-¹³¹ I was synthesized by the exchange reaction of 6-IP with Na¹³¹ I. Specific activity of synthesized 6-iodopurine was 0.42 mCi/mg (0.52 mCi/ml), and the yield of 6-iodo purine-¹³¹ I was 52%. The autoradiol ysis was not detected in 25 days. Studies of distribution of 6-iodopurine¹³¹ I in mice and scintiphotography indicated that the intraperitoneally injected 6-iodopurine-¹³¹ I-was incorporated into the stomach and tumor.
Considerably large amount of 6-iodopurine-¹³¹ I was found in the implanted tumor tissue 2 hours after intraperitoneal injection.
Incorporation of 6-iodopurine-¹³¹ I in tumor nucleus was showed by the microautoradiography.