Synthesis of Tritium-Labelled Chlorobiphenyls for the Use of Tracer Experiments

Abstract

Tritiated Kanechlol 400 was synthesized for the use of tracer experiments in the following procedure. 2- and 3-Bromobiphenyls were catalytically debrominated with tritium gas to give the corresponding tritiated biphenyls. 4-Tritiated biphenyl was obtained by decomposing Grignard reagent with tritium oxide. Three isomers of tritiated biphenyl were chlorinated using chlorine gas in the presence of ferric chloride in neat to provide Kanechlol 400-³H in good yields, of which radiochemical purity was characterized on radio gas chromato graphical analysis.