Accumulation and Excretion of ¹³¹I-Tagged Cholecystographic Contrast Medium for Intravenous Use

Abstract

For the purpose of studying the vicarious excretion of X-ray contrast agents isotopic experiments on the accumulation and excretion of Cholecystographic contrast medium were performed using radioactive ¹³¹I-meglumine iodipamide (¹³¹I-iodipamide) . Concentrated accumulation of ¹³¹I-iodipamide was occurred within 10 minutes of the intraperitoneal injection principally by the liver and was rapidly eliminated from the organs or body of the mouse within four hours. The urinary and fecal excretion of iodipamide was 7.7 and 92.2 per cent of injected dose. Maximal accumulation within the liver, kidney, and small bowel was 13, 6, 0.5 and 8, 6 per cent of total given dose at 30 minutes after injection respectively. Very little accumulations by the other organs including thyroid gland were revealed.
Scintigram at ten minutes after intravenous injection of 400μCi ¹³¹I-iodipamide in man showed rich uptake of contrast medium by the liver and followed by accumulation, excretion and contraction within the gallbladder and distribution in small and large bowel. This investigation suggested a possibility that scintigraphy with ¹³¹I-iodipamide may be a handy method for examination of gallbladder function.