The Measurement of Transit in the Gastrointestinal Tract Using ¹⁹⁸Au-colloid

Abstract

This study was undertaken to clarify the suitability of¹⁹⁸Au-colloid andNa₂⁵¹CrO₄for a marker of transit in the gastrointestinal tract.
The distribution, the excretion into the feces and urine, the absorption and excretion through the gastrointestinal tract were investigated in mice by means of sample measurement and whole body autoradiography.
Orally administered¹⁹⁸Au-colloid was not absorbed from the gastrointestinal tract and all was excreted into the feces.¹⁹⁸Au-colloid was not adhered to the gastrointestinal mucosa and consequently, the excretion into the feces was not delayed.
On the other hand, orally administeredNa₂⁵¹CrO₄was relatively well absorbed from the gastrointestinal tract, distributed to the whole body and a part of it was excreted into the urine. Intravenouslly injectedNa₂⁵¹CrO₄was excreted into the gastrointestinal tract.
It is concluded from the results obtaind that¹⁹⁸Au-colloid is available for a marker of gastrointestinal transit butNa₂⁵¹CrO₄is unavailable.