RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Metabolism of Chinoform (5-chloro-7-iodo-8-quinolinol) -14C in Dog
Goro URAKUBOYasumasa KIDOHideharu IKEBUCHIKunisuke NAGAMATSU
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1975 Volume 24 Issue 7 Pages 473-478

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Abstract

Chinoform (5-chloro-7-iodo-8-quinolinol) -14C (302.4μCi/83 mg) packed in a capsule was given orally to a dog weighing 10.5 kg and urine and feces were collected for 5 days after dosing. The excretions of large portion of radioactivities in urine and feces were observed at the 1st day and 3rd day after dosing, respectively. The total radioactivity in both excreta in 5 days was about 70% of dose, and the urine was used for the study of metabolites.
The urine was extracted with a mixture of benzene and pyridine (9: 1), and organic layer and aqueous layer were obtained.
Intact chinoform and 5-chloro-8-quinolinol (a deiodinated product of chinoform) were identified in the organic layer by radiochromatography and isotope dilution method. From the water layer of urine, glucuronides of chinoform and the deiodinated product, and sulfate of chinoform were identified as the metabolites.

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© Japan Radioisotope Association
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