Affinity for a Malignant Tumor and Organs at the Elements in Group VI of the Periodic Table

Abstract

In order to investigate the tumor affinity radioisotopes, chromium (⁵¹Cr), molybdenum (⁹⁹Mo), tungsten (¹⁸¹W), selenium (⁷⁵Se) and tellurium (^127mTe) -the elements of group VI in the periodic table-were examined, using the rats which were subcutaneously transplanted with Yoshida sarcoma. Seven preparations, sodium chromate (Na₂⁵¹CrO₄), chromium chloride (⁵¹CrCl₃), normal ammonium molybdate ( (NH₄) ₂⁹⁹MoO₄), sodium tungstate (Na₂¹⁸¹WO₄), sodium selenate (Na₂⁷⁵SeO₄), sodium selenite (Na₂⁷⁵SeO₃) and tellurous acid (H₂^127mTeO₃) were injected intravenously to each group of tumor bearing rats. These rats were sacrificed at various periods after injection of each preparation: 3 hours, 24 hours and 48 hours in all preparations. The radioaetivities of the tumor, blood, muscle, liver, kidney and spleen were measured by a well-type scintillation counter, and retention values (in every tissue including the tumor) were calculated in percent of administered dose per g-tissue weight.
All of seven preparations did not have any affinity for malignant tumor. Na₂⁵¹CrO₄ and H₂^127mTeO₃ had some affinity for the kidneys, and Na₂⁷⁵SeO₃ had some affinity for the liver. Na₂¹⁸¹WO₄ and (NH₄) ₂⁹⁹MoO₄ disappeared very rapidly from the blood and soft tissue, and about seventy-five percent of radioactivity was excreted in urine within first 3 hours.