Bone Scintigraphy with ^99mTc-EHDP

Abstract

Bone scintigraphy with ^99mTc-EHDP (ethane-1-hydroxy-1, 1-diphosphonate) was performed in 22 cases of primary bone tumors, metastatic bone tumors and other diseases, using a scintillation camera and mini-computer system.
Excellent skeletal images were obtained in 19 cases (86.4%) while other 3 were not so excellent, but all of them were helpful for clinical diagnosis.
In the cases of primary bone tumors with high malignancy, the uptake of ^99mTc-EHDP in the lesions was observed about twice or higher than of healthy opposite side. And in other cases including metastatic bone tumors, the uptake was observed not more than 1.5 times.
In all 4 cases of metastatic bone tumors showed positive scintigrams, although in 2 of them, their plain X-ray photographs showed no abnormality.
It was observed that scintigraphy with this agent was useful for differential diagnosis of the lesions and the demonstration of early metastasis in bone.
None of the patients showed any adverse reaction of ^99mTc-EHDP in administration.