RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Distribution of Heparin-67Gai in Tumori-Bearing Rats
Tatsunosuke HIRAKIAtsushi ANDOItsuko ANDOShigeru SANADAKinichi HISADA
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1976 Volume 25 Issue 6 Pages 329-332

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Abstract

Heparin is a kind of acidic mucopolysaccharide. Heparin-67Ga complex was prepared to investigate distribution in tumor-bearing rats. This compound was intravenously injected to the rats subcutaneously transplanted Yoshida sarcoma. These rats were sacrificed at 10 minutes, 30 minutes, 1 hour and 3 hours after injection. The radioactivities of the tumor, blood, muscle, liver, kidney, spleen and urine were measured by well-type scintillation counter. The retention values in these organs and the excretion rates in the urine were calculated. Excretion rates (%/dose) of heparin-67Ga in 10 min., 30 min., 1 hours and 3 hours were 38.2%, 67.5%, 79.5% and 78.0%, respectively. From these facts, it was thought that heparin-67Ga complex had not suitable property for tumor scanning, but this compound might be suitable agent for renal function test.

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© Japan Radioisotope Association
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