Study of Distribution of ²⁰³Hg-chlormerodrin, ²⁰³Hg-nitrate and ^99mTc-DMSA in Kidney by Macroautoradiography

Abstract

Serial macroautoradiograms were obtained to determine the distribution of ²⁰³Hg-chlormerodrin, ²⁰³Hg-nitrate and ^99mTc-DMSA in kidney. In the study, normal rats were used and these three radiopharmaceuticals were injected intravenously.
Initial images of ²⁰³Hg-chlormerodrin showed the accumulation in the outer cortex, but no significant radioactivity in the medullary. On the other hand, delayed images revealed radioactivity shifting in concentration from the outer cortex to the inner cortex. Distribution pattern of ²⁰³Hg-nitrate was similar to that of ²⁰³Hg-chlormerodrin. In contrast to ²⁰³Hg-chlormerodrin and ²⁰³Hg-nitrate, ^99mTc-DMSA was retained in the outer cortex without temporal changes in the distribution.