Renal Function Study with ¹¹¹In-DTPA

—In comparison with ^99mTc-DTPA—

Abstract

Technetium-99m-diethylene-triamine penta-acetic acid (DTPA) and ¹¹¹In-DTPA were injected simultaneously into 21 patients with various levels of renal function. Scintiphoto, camera data renograms and clearance values (plasma sampling) were obtained for each patient.
The mixed isotope scintiphoto images were of intermediate quality and the images with ¹¹¹In-DTPA were apparently inferior to those with ^99mTc-DTPA.
These equations were obtained:
(1) y=0.30+0.91x (coefficiency of correlation r=0.98) where x is the value at T peak (time of maximum count on renogram) obtained with ^99mTc-DTPA and where y is the value at T peak with ¹¹¹In-DTPA.
(2) y=-0.09+1.006x (r=0.99) where x is the value at T_3/4 (time interval between the time of maximum count to the time of 3/4 of maximum count on renogram) and where y is the value at T_3/4 obtained with ¹¹¹In-DTPA.
(3) y=-0.01+1.007x (r=0.98) where the x and y values were for the excretion ratios (counts at 20 min/maximum counts on renogram) .
(4) y=0.81+0.98x (r=0.99) where x and y are the clearance values.