RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Synthesis of [3-2H] - and [3-3H] -Cianidanol
Susumu MIURAToshifumi MIDORIKAWANorio AWATA
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1983 Volume 32 Issue 5 Pages 225-230

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Abstract

In order to study the metabolism of cianidanol (I), [3-2H] - (I) and [3-3H] - (I) were synthesized.
(I) was benzylated and then oxidized with DMSO-Ac2O to give 2R-3', 4', 5, 7-tetrabenzyl-cianidan-3-one (III) .
(III) was reduced with NaB2H4 or NaB3H4, and then debenzylated to give [3-2H] - (I) or [3-3H] - (I) . [3-2H] - (I) was obtained with the over all yield of 21% from NaB2H4. In the other hand, [3-3H] - (I) was obtained with the over all yield of 23% from NaB3H4.

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