Renal Blood Volume vs. Glomerular Filtration Rate: Evaluation with C¹⁵O and ⁶⁸Ga-Ethylenediaminetetraacetic Acid (EDTA) Study

Abstract

⁶⁸Ga-EDTA (ethylenediaminetetraacetic acid) is simply and economically obtained without a cyclotron. We used renal blood volume (RBV) values obtained by C¹⁵O studies for blood activity subtraction on renal time activity curves using a positron emission tomography for the determination of the glomerular filtration rate (GFR) by intravenous ⁶⁸Ga-EDTA administration. Positive correlation was revealed between the GFR and RBV values, where the ratio of blood activity in whole renal activity increased relatively as GFR value decreased. The estimation using a correction equation derived from the correlation curve was possible without a C¹⁵O study.