RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Evaluation of 3H-Paroxetine as a Radioligand for in vivo Study of 5-Hydroxytryptamine Uptake Sites in Mouse Brain
Kenji HASHIMOTOTsuyoshi GOROMARU
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JOURNALS FREE ACCESS

1990 Volume 39 Issue 8 Pages 335-341

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Abstract

The distribution of radioactivity in the mouse brain after intravenous administration of 3H-paroxetine was in the order (highest to lowest) hypothalamus>cerebral cortex>cerebellum. The radioactivity in the hypothalamus and cerebral cortex after injection of 3H-paroxetine was significantly decreased by treatment with 6-nitroquipazine or paroxetine. HPLC and TLC analyses show that no radioactive metabolites were found in the mouse brain 3 h after intravenous administration of 3H-paroxetine. The present results indicate that 3H-paroxetine would be a suitable radioligand for in vivo study of 5-HT uptake sites in mouse brain.

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© Japan Radioisotope Association
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