RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
γ線亜致死線量照射後のマウスに対する塩化コバルトの皮下1回投与による放射線防護効果
出雲 義朗緒方 裕光
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ジャーナル フリー

1993 年 42 巻 3 号 p. 164-168

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Radioprotective effects were investigated in mice which received subcutaneously a single dose of each inorganic metal: Co, Cu, Rb, Sr, Mo and W 24h post irradiation of 60Co γ-rays with a sublethal dose.
The effects were observed in mice injected with Co at an optimum dosage of 20 mg/kg· body weight. Then to elucidate mechanisms of the effects, mice were injected with Co containing the radioactive tracer (60Co) following the radiation exposure, measured elimination of the radioactivity for 7 days, then sacrificed and divided to some tissues and organs. The radioactivity in whole body during this period resulted in a markedly higher retention than that for mice injected with [60Co] alone, as well as liver in the organs. These higher retentions appeared to be related to the radioprotective effects.

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