99mTc-GSAによる肝機能指標LU3, LU15の検討

篠原 広行; 長谷部 伸; 國安 芳夫; 宮下 信; 桑山 潤; 新尾 泰男; 吉岡 克則; 河窪 雅宏; 山下 文明

doi:10.3769/radioisotopes.43.346

A Study on the Liver Function Indices LU3 and LU15 with ^99mTc-GSA

Hiroyuki SHINOHARA, Shin HASEBE, Yoshio KUNIYASU, Makoto MIYASHITA, Jun KUWAYAMA, Yasuo NIIO, Katunori YOSHIOKA, Masahiro KAWAKUBO, Fumiake YAMASHITA

Author information

Hiroyuki SHINOHARA
Department of Radiology, Showa University, Fujigaoka Hospital
Shin HASEBE
Department of Radiology, Showa University, Fujigaoka Hospital
Yoshio KUNIYASU
Department of Radiology, Showa University, Fujigaoka Hospital
Makoto MIYASHITA
Department of Radiology, Showa University, Fujigaoka Hospital
Jun KUWAYAMA
Department of Radiology, Showa University, Fujigaoka Hospital
Yasuo NIIO
Department of Radiology, Showa University, Fujigaoka Hospital
Katunori YOSHIOKA
Division of Nuclear Medicine, Yokokawa Medical Systems
Masahiro KAWAKUBO
Division of Nuclear Medicine, Yokokawa Medical Systems
Fumiake YAMASHITA
Division of ME service

Keywords: technetium-99m-diethylene triamine pentaacetic acid-galactosyl human serum albumin, liver function, receptor

JOURNAL FREE ACCESS

1994 Volume 43 Issue 6 Pages 346-349

DOI https://doi.org/10.3769/radioisotopes.43.346

Details

Abstract

Correlation of LU3 (LU15) which represents the cumulative uptake of^99mTc-GSA from 3 (15) to 4 (16) min after injection and hepatic blood flow or receptor quantity was studied. The subjects consisted of 14 patients, including 13 patients with liver cirrhosis or chronic hepatitis and 1 patient with normal liver. LU3 and L U15 showed a good correlation with the ratio of^99mTc-GSA binding to receptor and the total injected^99mTc-GSA, estimated by whole body scan. LU3 and LU15 also well correlated with the maximal removal rate by nonlinear compartment model, on the other hand, they showed a poor correlation with the hepatic blood flow. It was concluded that LU3 and LU15 chiefly reflect the amount of receptors in the liver.

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