Abstract
A comparative study in Wistar normal rats and ODS rats unable to synthesize ascorbic acid showed that the radioactivity distribution in tissues after i. v. injection of 6-deoxy-6- [18F] fluoro-L-ascorbic acid (18F-DFA) was not significantly influenced by the vitamin C status of the animal. Biodistribution studies in Wistar male rats implanted with RG-C6 glioma intracerebrally demonstrated that 18F-DFA had low tumor localization (0.17% dose/g at 30 min and 0.16% dose/g at 60 min) with very little specific distribution compared with non-target brain tissues. These results indicate that the use of 18F-DFA may not be a candidate for imaging brain tumor by PET.
