Evaluation of Regional Cerebral Blood Flow Changes in Normal Aging Using ^99mTc-ECD SPECT and Patlak Method

Abstract

Changes in regional cerebral blood flow (rCBF) were studied using^99mTc-ECD SPECT and Patlak method in 47 subjects, aged 1 to 79 years (mean 28.5 years) . No abnormal finding was found on MR imaging in the subjects. We obtained mean cerebral blood flow (mCBF) by means of Patlak method. rCBF was measured by positioning regions of interest (ROIs) in frontal lobe, parietal lobe, temporal lobe, occipital lobe, cerebellum and thalamus. The correlation coefficient between ages and mCBF was r=-0.897 (p<0.0001) . mCBF of children was significantly higher (p<0.05), compared with adults. By dispersion analysis according to the groups of ages, significantly higher rCBF values were available in the frontal, parietal, temporal and occipital lobes during childhood than adulthood (p<0.05), but there were almost no significant differences of rCBF during childhood than adulthood in cerebellum and thalamus.