An automated system for preparation of11C-methylated compounds from [11C] methyl iodide, manufactured bySumitomo Heavy Industries Ltd., was adapted for the loop labeling method using [11C] methyl tiflate. Two 2-way valves on an exchangeable tray were replaced with 3-way valves and a furnace for heating anAgOTfcolumn at 200°C was added. The automated system successfully produced [11C] raclopride and [11C] N-methyl-3-piperidyl benzilate in 0.96-1.1GBq and 1.0-1.3 GBq, respectively, at 40 min after the end of bombardment.
