2025 Volume 52 Issue 5 Pages 267-275
Objective: This study evaluated the safety and efficacy of high-frequency rehabilitation for patients with acute stroke between the first 48 h after stroke onset and 14 days following stroke onset.
Methods: A non-randomized controlled trial was conducted at Kansai electric power hospital between August 2017 and December 2019. This study included 397 patients with acute stroke who were divided into the high-frequency rehabilitation (HF) and control groups. The primary outcomes were modified Rankin Score (mRS) and Functional Ambulation Categories (FAC) at discharge. The secondary outcomes were immobility-related complications and neurological adverse events.
Results: The HF and control groups included 121 and 93 patients, respectively. The mRS (<2) was not significantly different between the two groups. The FAC (>2) was significantly higher in the HF group than in the control group. Immobility-related complications and neurological adverse events were not significantly different between the two groups.
Conclusions: Frequent rehabilitation for 14 days, starting with standing within 48 h of onset, can be safely performed in patients with stroke and supratentorial lesions and in conservatively treated patients and may improve ambulatory independence.
