Abstract
It is a well-known fact that breast cancer is estrogen-dependent, however, there are fewer findings on the relations with other hormones. We report a relation between breast cancer and growth hormone (GH) through our experience of a rare case of breast cancer associated with acromegary, together with a review of the literature.
A 43-year-old female underwent extended radical mastectomy due to left breast cancer, which was a hard cancer histologically and in stage II with T2n1βm0. Before surgery her characteristic looks made us suspect of acromegary, and endocrinologic examinaiton, pituitary fossa X-P, CT scanning of the head revealed a pituitary adenoma (GH producing tumor). After mastectomy excision of adenoma was carried out transsphenoidally. Histologically it was oxyphilic adenoma.
As shown in this case in which the cancer was a histologically hard type, regional lymphnodes were positive, and DNA histogram due to flow Cytometry was aneuploid, as well as the cumulated findings reported up to now, it has been suggested that GH possibly enhances proliferation of the tumor and worsens the malignancy.
