Most cases of pancreatic cancer are found in an advanced stage, and are often associated with involvement of adjacent vessels. In the cases of segmental resection of the portal vein, a repair of the gap with end-to-end anastomosis is recommended. Vascular prosthesis or autogenous vein, however, is necessary when a long segment of portal vein had to be resected. We have used EPTFE grafts on 4 cases of carcinoma of the pancreas where the resection of the tumor would caused and impossibility of making the direct end-to-end anastomosis. Excluding one case where the patient died of another disease three months after the operation, remaining three cases are reviewed here. The graft was patent in two cases. In one case, the graft is patent for 4 years and 4 months and this patient is still alive. In the other case, it was patent for 1 year and 10 months, but this patient died of recurrent cancer 1 year and 11 months after the operation. Graft was, however, occluded 6 months after the operation in one patient who died 1 year and 8 months after the operation. In this paper, our evaluation of replacement of portal vein with EPTFE vascular prosthesis is presented, based on our clinical experiences.