EFFECTIVENESS OF THE EDNDOTOXIN ADSORPTION METHOD IN PATIENTS WITH PERFORATION OF THE COLON

Abstract

In a recent 8-year period since January 1989, 29 patients with perforation of the colon were treated at the department. The leukocyte count, platelet count, and urea nitrogen concentration up to postoperative day 7 were compared according to systemic inflammatory response syndrome (SIRS) status. Group I (7 patients) was negative for SIRS. Group II (13 patients) was positive for SIRS and Group II patients were subdivided into group II-1, consisting of eight survivors and group II-2, consisting of five patients who died. Group III (9 patients) was positive for SIRS and underwent PMX. As compared with the
preoperative leukocyte counts in group I (7400 ± 4100/mm³) and group II (8800 ± 6600/mm³), the value in group II-1 (12900 ± 1600/mm³) was high and those in group II-2 (2400 ± 1600/mm³) and group III were very low (2500 ± 1200/mm³).
Postoperatively, however, the leukocyte count increased with time to 9800 ± 4300/mm³ on postperative day 7 in patients who underwent PMX, which was significantly higher than the value in group II-2. Similar trends were seen for the platelet count and urea nitrogen concentration. Our results suggest that PMX is effective for improving the status of patients who are positive for SIRS.