The subject was a 43-year-old woman. She found a painless tumor in the AC region of the right mamma and visited hospital. By palpation, US and MMG, right breast cancer of T1aN0M0stage I was diagnosed, and underwent operation. Histopathological examination of a biopsied frozen section confirmed a definitive diagnosis of invasive adenocarcinoma, and breast conservative surgery was performed. However, in the histopathological examination of the resection stump, ductal spreading of cancer cells were found, and additional total mastectomy was conducted 10 days later. In the macroscopic examination, a gray-white solid tumor 15×10mm in size at a section surface was found. Histologically, the tumor consisted of solid-cell nests with trabecular arrangements, and cartilaginous metaplasia in the cancer. Consecutive transition between the cancer and metaplastic area was noted. In the region of adenocarcinoma, a component of the solid-tubular carcinoma was dominant. All of the n0, ly0, v0, EIC(+), ER and PGR were negative. Breast cancer with cartilaginous and osseous metaplasia belongs to a special type of invasive carcinoma, and the incidence is very rare. Only about 60 cases of this type have been reported in Japan. We present the clinical characteristics and examine prognostic factors of this cancer.
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)