Abstract
Basophilic leucocytes in peripheral blood and bone marrow of 13 cases of CML were calculated by our improved method. The results of these calculations were used to form basophilograms. The basophilogram in healthy controls showed a left type and that in CML generally a right type. It shifted to the left approaching to the normal type in remission by chemotherapy. In an aggravation of CML, the basophilogram clearly shifted to the right. The basophilogram in 2 cases of pre-stage of blastic crisis of CML indicated a definite right type. S type, sharply defined granules, and diffuse N type in III and IV type of basophilogram were classified, and it was shown that an increase of S type occurred in the aggravation stage. Consequently, appearance of S type as well as a right type in basophilogram would be a useful guide in the follow-up of CML. A basophil of S type was considered to be immature. The bone marrow basophilogram was shown to be more shifted to the right than that of peripheral blood, and this tendency became more remarkable in relapse. The fact that there are a right type in basophilogram and appearance of S type is significant for the observation of the clinical course in CML, especially in the judgment of acute exacerbation.
