Abstract
The inhibiting activity on blood coagulation by a new synthetic substance having a chemical structure of 4-(2-carboxyethyl) phenyl-trans-4-aminomethyl cyclohexane carboxylate hydrochloride was studied in vitro. The results obtained were as follows:
1. The substance exerted a highly potent inhibiting activity on thrombin. The kinetic study by employing the technique of Lineweaver and Burk revealed that the inhibition was competitive in fashion.
2. In addition, the substance inhibited either or both of process of the first phase of blood coagulation in which factor IXa→IX and IXa (factor VIII, phospholipid and calcium ions)→X interactions were involved.
