抄録
A 39-year-old male patient with severe anemia, jaundice and episodes of hemoglobinuria was diagnosed to have PNH, because of positive Ham and sucrose hemolysis tests, and decreased erythrocyte acetylcholinesterase activity in addition to the usual findings found in hemolytic anemia. The patient showed complex clinical manifestations of the disease and serum hepatitis. Elevated serum GOT and LDH persisted constantly in the whole course of the disease.
He frequently developed hemolytic crisis followed by hemoglobinuria after the intravenous as well as peroral iron administration for the treatment of iron deficiency anemia. The hemolytic crisis has been, however, markedly supressed when iron is administered in combination with a small dosis of steroid hormone. Vitamin E was also found to be effective for the improvement of the laboratory findings.
He died suddenly of hemolytic crisis, complicated by bronchopneumonia and uremia.
