抄録
Peripheral leukocytes from a male patient with chronic myelogenous leukemia in blastic crisis were implanted directly into the intraperitoneal cavity of seven newborn hamsters treated with antilymphocyte serum. At sacrifice 17 to 19 days after implantation, three hamsters were found to have disseminated tumors. The four other hamsters were cannibalized. Chromosome analysis of cells from the enlarged lymph nodes revealed the presence of a human male karyotype. Most metaphase cells were pseudodiploid with the Ph1 chromosome and isochromosome 17, while a few metaphase cells were classically diploid. Identical chromosome constitutions were observed in the original peripheral leukocytes of the patient. The results indicate simultaneous heterotransplantation of Ph1-positive leukemic and normal leukocytes.
