抄録
46 children diagnosed as having aplastic anemia from 1964 to 1976 have been treated with oral administration of oxymetholone (1-2 mg/kg/day) and prednisolone (0.25∼0.5 mg/kg/day) in most of patients. They consisted of 5 constitutional patients and 41 patients with acquired type (idiopathic: 25, posthepatitic: 6, drug-induced: 6, postviral infection: 4). 3 acquired patients due to chloramphenicol died within one month after start of the therapy and were excluded. 16 of 38 patients with acquired type (42%) and 2 of 5 constitutional patients achieved complete remission by this regimen, followed by no more relapse. 11 of remaining acquired patients had temporary remission, but they repeated relapses afterwards and some of them terminated in death after one to five years course. Another eleven patients with acquired patients and 3 constitutional patients did not respond at all in spite of a long term treatment. There was no significant relationship between dosis of oxymetholone (1 or 2 mg/kg/day) and responsiveness to this regimen. Although the children with below 10,000 reticulocytes/μl on the first admission had apparently grave prognosis, 7 of 19 acquired patients in severe group (37%) and 15 of 22 patients in non-severe group (68%) had remission by this regimen anyhow. This regimen resulted in no significant retardation of their growth and developement.
