—Three Cases of Lazy-leukocyte Syndrome—

Abstract

We reported three children with lazy-leukocyte syndrome who had suffered from recurrent pyogenic infections and stomatitis since early infancy.
They were unrelated each other and their family history was unremarkable.
All of the patients had severe neutropenia (59∼204/cmm) despite normal peripheral leukocyte counts, and their neutrophils were defective in chemotaxis and random mobility.
The bone marrow pictures were normal: there were normal numbers of neutrophils at every stage of maturation and their morphology was normal.
Humoral and cellular immunity tests such as serum IgG, A and M levels, T and B subpopulations, lymphocyte blastogenesis, and PHA skin test were normal.
Lymphocyte derived chemotactic factor (LDCF) production studied in one of them was normal.
Further hematologic and immunologic studies are needed to disclose the mechanism of the defective neutrophil mobility in this syndrome.