A Case of Multiple Myeloma with Double M-Proteins of IgG-κ and IgA-κ

Abstract

A 70-year-old woman with multiple myeloma is described. She had diphasic IgG-κ and IgA-κ type M-proteins in serum and a κ-type Bence-Jones protein in urine. Examination of myeloma cells with immunofluorescent and immunoenzyme assay showed a heterogeneous staining patterns. However, with both methods, it was found that the some cells were stained with the both antisera. From these results, it was suggested that most of the myeloma cells from the patient secreted of the two immunoglobulins but some of the cells secreted both immunoglobulins.