抄録
Red cell life span was determined before and after the administration of dilazep in 4 patients with chronic renal failure undergoing hemodialysis and in a patient with elliptocytosis. By computer analysis of 51Cr-RBC disappearance curve, mean red cell life span (MRCLS), half survival (t1/2), relative survival rate (RSR), and exponential 51Cr-disappearance rate (k) were obtained.
After the administration of dilazep, MRCLS and RSR were increased in 4 cases, T1/2 was increased in 3 cases, and k was decreased in 3 cases out of 5 cases. 51Cr-RBC disappearance curves obtained before and after administration of dilazep were superimposed for comparison. It was taken for the change of red cell destruction, when the two curves were visually separated beyond the width of ±1 standard deviation each. By the above method of differentiation, red cell destruction was decreased in 2, not changed in 3, and increased in none out of 5 cases.
The observed tendency of decrease of red cell destruction seems to be related to the effect of delazep.
