A Case of Acute Myelomonocytic Leukemia with Bone Marrow Eosinophilia, Associated with Pericentric Inversion of Chromosome 16

Abstract

A 53-year-old man referred to the Saiseikai Fukushima General Hospital on December 10, 1984, with chief complaints of meteorism, anorexia, general fatigue and fever.
On admission, the white blood cell counts were 60,300/cmm with 63% leukemic cells consisting of 14% myeloblasts, 2% promyelocytes and 47% immature monocytes. A bone marrow aspirate showed hypercellularity with 15.2% myeloblasts, 28.0% immature monocytes and 24.4% mature and immature eosinophils. The findings of peroxidase or esterase staining and of serum or urine muramidase activity supported the diagnosis of acute myelomocytic leukemia (M₄). Cytogenetic analyses revealed 46, XY, inv (16) (p13q22).
Complete remission was achieved after one course of chemotherapy consisting of aclarubicin, enocitabine, 6-mercaptopurine and prednisolone. In the beginning of January 1985, icterus, ascites and pleural effusion became remarkable probably due to liver cirrhosis and he died of acute respiratory failure on January 17, 1985.