Abstract
A 33-year-old houswife was diagnosed to have acute nonlymphocytic leukemia in April, 1980. Complete remission was achieved by the DCV (daunorubicin, cytarabine, and vincristine) therapy. Meningeal leukemia developed in hematological remission in May, 1981 which was successfully treated by intrathecal methotrexate. In July, 1982 a painful abdominal mass, extending from the pelvis to the umbilicus, was found, and leukemic infiltration was confirmed in the uterus and ovaries by CT scanning and biopsy. Irradiation was effective to reduce the size of the tumors and to eradicate leukemic cells as shown later in the resected uterus and ovaries. In September of the same year, paraplegia occurred below the 7th thoracic level, which was proved by myelography and CT scanning to result from a spinal tumor.
The neurological signs were improved by irradiation.
The first hematological relapse occurred in October, 1983 in association with pleural effusion containing numerous leukemic blasts. Bone marrow remission was again achieved and pleural effusion disappeared by the BHAC-AMP (enocitabine, aclarubicin, 6-mercaptopurine, and prednisolone) therapy. Currently, the patient is doing well four years and four months after the onset of her disease.
