Abstract
A case of chronic lymphocytic leukemia associated with multiple myeloma (Bence Jones lambda type) was reported.
A 69 year old man was admitted to Nippon Kokan Hospital in June 1982, because of anorexia and weightloss.
Blood examination showed RBC 155×104/mm3, Hb 5.5 g/dl, WBC 25,700/mm3 with 72.8% lymphocyte, platelet 10.2×104/mm3, total protein 6.1 g/dl (gammaglobulin 18.5%, IgG 760 mg/dl, IgM 26 mg/dl, IgA 24 mg/dl), and severe renal dysfunction.
The number of mature small lymphocyte and atypical plasma cell were increased in bone marrow.
Immunoelectrophoresis showed Bence Jones lambda paraproteinemia. From these data, the diagnosis of chronic lymphocytic leukemia associated with multiple myeloma was made on him who was treated with predonisolone and cyclophosphamide, but died of sepsis in August 1982.
The analysis of enzyme labeled antibody method showed that immunoglobulin (lambda) was found in the margin of mature small lymphocyte and in the cytoplasma of atypical plasma cell.
It is conceived that chronic lymphocytic leukemia and multiple myeloma in this case was derived from the same clonal origin of B cells.
