Abstract
A 55 year-old-woman was admitted to our hospital with complaints of high fever and back pain in April, 1983. One year prior to admission she was treated as Ph1 positive CML with myelofibrosis.
By physical examination and laboratory findings, she was suspected of blastic phase of CML. After treatment with ACNU and DBM, she suffered for severe bone marrow hypoplasia for 3 months. Although she complicated with candidiosis of spleen and liver, she entered in complete remission lasting one year. During that time, chromosome analysis of bone marrow revealed marked reduction of Ph1 positive cells. In August, 1984, she died of systemic fungal infection with DIC.
Autopsy findings revealed mild myelofibrosis but no evidence of extramedullary hemopoiesis. This case was diagnosed as atypical myeloploliferative disorder.
