Abstract
The clinicopathologic findings of 24 autopsy cases of the myelodysplastic syndromes (MDS) including 8 cases of the refractory anemia with excess of blasts (RAEB), 4 cases of the RAEB in Transformation (RAEB in T), 3 cases of the refractory anemia, 5 cases of the chronic myelomonocytic leukemia and the other 3 cases were reported.
The conclusions in this study were followings:
(1) The RAEB was characteristic myeloproliferative state and there were seven of eight cases which terminated in overt leukemia.
(2) The leukemia with MDS showed characteristic autopsy findings compared with typical acute non-lymphocytic leukemia.
(3) It was difficult that we expected the outcome of the disease by the only histological findings of bone marrow in early stage.
(4) It was considered that the RAEB in T had more neoplastic nature.
(5) In the cases with hypoplastic bone marrow, there were some cases which had marked morphologic dysplasia in various hemopoietic cells.
(6) Cytochemical stains, immunohistochemical study and electron microscopic observation are necessary to identify the blasts and variegated morpholigic abnormality of hemopoietic cells.
