Two Cases of Allogeneic Bone Marrow Transplantation with Psychoneurological Symptoms possibly due to Hypomagnesemia caused by Ciclosporin A

Abstract

We experienced two cases of psychoneurological symptoms, who were given ciclosporin A (CYA) to minimize graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation; one was a generalized convulsion, and the other tremor and depression. Both symptoms occured when serum magnesium level became low, and released by elevated magnesium level.
We considered these symptoms were due to hypomagnesemia caused by CYA, as same as two papers had been published.
Although the cause of hypomagnesemia caused by CYA is not yet known, there are some occasions of hypomagnesemia in cases of allogeneic bone marrow transplantation given CYA for the treatment of acute leukemia, we suggest that adequate magnesium replacement is important for prevention of such psychoneurological symptoms.