臨床血液
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
臨床研究
小児悪性腫瘍に対するRecombinant Human G-CSF(rG·CSF注)の臨床検討
月本 一郎塙 嘉之高久 史麿浅野 茂隆上田 一博土田 昌宏佐藤 武幸大平 睦郎星 順隆西平 浩一中畑 龍俊今宿 晋作秋山 祐一櫻井 實宮崎 澄雄堺 薫内海 治郎黒梅 恭芳古川 利温山本 圭子関根 勇夫麦島 秀雄矢田 純一中沢 真平小出 亮加藤 俊一金子 隆松山 秀介堀部 敬三小西 省三郎多和 昭雄筒井 孟高上 洋一田坂 英子植田 浩司
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1990 年 31 巻 10 号 p. 1647-1655

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Recombinant human granulocyte colony-stimulating factor (rG-CSF), produced by Chinese hamster ovary cells, was administered in 69 chemotherapy-induced neutropenic pediatric patients (pts) with malignant tumors. Each pt received two cycles of the same chemotherapy and had neutropenia with absolute neutrophil counts (ANC) <500/μl in the first cycle. Initiating 72 hours after termination of chemotherapy in the second cycle, rG-CSF (2 μg/kg/day) was given subcutaneously or intravenously to each pt for 10 days. rG-CSF significantly increased ANC at nadir; 72±14 vs. 206±40/μl (data in the first cycle vs. data in the second cycle, respectively), and reduced the period of neutropenia with ANC<500/μl; 9.7±0.6 vs. 5.1±0.6 days, and the period for restoration to ANC≥1,000/μl after initiation of chemotherapy; 25.5±0.6 vs. 17.5±0.9 days. rG-CSF did not affect other components of peripheral blood. The number of days with fever ≥38°C was significantly reduced by rG-CSF treatment. Neck pain and lumbago were observed in one pt, polakysuria in one pt, and elevation of the serum levels of LDH and uric acid in one pt, however these were mild to moderate, transient, and resolved without any specific treatment. We concluded that rG-CSF was effective in neutropenia induced by intensive chemotherapy for malignant tumors without any serious side effects.

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© 1990 一般社団法人 日本血液学会
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