II Treatment Results of Intermittent and Cyclic Regimen with ATRA and Chemotherapy in Childhood Acute Promyelocytic Leukemia

Abstract

An intermittent and cyclic regimen with All-Trans Retinoic Acid (ATRA) and intensive chemotherapy was conducted due to pharmacokinetic studies on ATRA for acute promyelocytic leukemia (APL) in children. We have treated 17 children with APL using ATRA for remission induction followed by an intermittent schedule of ATRA plus intensive chemotherapy (APL-ATRA protocol). There were 10 males and 7 females. The median age was 9.0 years old. The median baseline white blood cell count was 12.1×10³/μl, hemoglobin 7.8 g/dl, platelet 4.5×10⁴/μl at diagnosis. Sixteen patients showed t(15;17) translocation. RT-PCR analysis was available in 15 patients and showed PML/RAR α rearrangement in all patients. Overall, 13 of 17 newly diagnosed patients (88%) achieved complete remission and EFS was 67%. Compared to the control (same chemotherapy without ATRA regimen), remission induction and EFS were significantly increased. The toxicity of ATRA consisted of retinoic acid syndrome in 1 and pseudotumor cerebli in another. Other toxicites included headache, chelitis, gastrointestinal trouble and bone pain. These results suggest that intermittent and cyclic regimen with ATRA and intensive chemotherapy (APL-ATRA protocol) is highly effective for APL patients.